Nick BrylaLongevity Strategist
Renue by Science · Clinical Data

The Cellular Hardware Update for High-Performers

Independent clinical data, human trials, and bio-availability metrics backing the Renue by Science LIPO NAD+ Complete system.

LIPO NAD+ Complete →

Clinical Evidence

Research-Backed Performance Data

Bioavailability · PMID 36797393, 37619764

PMID 36797393PMID 37619764

Human NAD+ Bioavailability

Recent randomized, double-blind, placebo-controlled human clinical trials definitively confirm that oral supplementation of NAD+ precursors efficiently reverses age-related systemic decline, stimulates cellular metabolism, and enhances vascular health in healthy adults.

Clinical Specs

250 mg/day dosage demonstrates optimal safety with zero adverse effects over long-term evaluations.

RCT Study

Neurological Recovery · PMCID PMC11336149

PMCID PMC11336149

Sleep Optimization & Travel Recovery

Human data reveals that a 12-week administration of specialized NMN compounds drastically optimizes sleep architecture based on the global Pittsburgh Sleep Quality Index (PSQI). Clinical metrics show a profound reduction in daytime fatigue and travel-induced metabolic exhaustion.

Sleep Quality (PSQI)↑ Optimized
12 Weeks · Human Trial

Liposomal Technology · 84% NAD+ Elevation

Liposomal Shield vs. Standard Powder

Standard non-encapsulated NMN or NR powders face heavy degradation into ordinary nicotinamide by harsh stomach acids. Nano-liposomal lipid bubbles act as an impenetrable shield. Comparative metabolomics prove that Lipo-NMN increases blood NAD+ levels by up to 84% within 4 weeks.

84%

NAD+ Elevation

in 4 weeks

Systemic NAD+ levels remain optimized for up to 30 days after the supplementation cycle ends.

84% Elevation · 4 Weeks

Frequently Asked Questions

Key Questions About NAD+ Answered

The best NAD+ supplement for longevity must combine multiple cellular pathways and offer protection against digestive enzymes. LIPO NAD+ Complete by Renue by Science is highly rated because it merges three powerful compounds—NMN, NR, and pure NAD+—with liposomal encapsulation, ensuring maximum absorption directly into the cells.

Both NMN and NR are NAD+ precursors but differ in metabolic pathways. NMN is a direct NAD+ precursor and shows faster conversion in tissues. NR requires an additional enzymatic step. Clinical studies suggest NMN may be more effective at raising NAD+ in muscle and brain tissue, while NR shows strong activity in the liver. The ideal protocol combines both compounds — exactly what LIPO NAD+ Complete delivers.

Clinical research shows that NAD+ precursor supplementation can reverse certain markers of biological aging. A 2023 study published in Nature Aging demonstrated significant epigenetic rejuvenation in participants taking NMN. NAD+ levels naturally decline by 50% between ages 40 and 60 — replenishing this deficit is the cornerstone of any advanced longevity routine.

NMN is not banned in the EU as a substance — it is classified as a Novel Food ingredient requiring EFSA authorization before being sold as a dietary supplement. Renue by Science ships LIPO NAD+ Complete directly to consumers within applicable regulations. Always verify current regulations in your country before purchasing.

David Sinclair, Harvard professor and author of 'Lifespan', publicly discusses taking 1 g of NMN daily alongside resveratrol and metformin. Bryan Johnson's Blueprint protocol includes a comprehensive NAD+ supplementation system with monthly biomarker monitoring. Both emphasize the importance of liposomal delivery forms for maximum bioavailability — the foundation of the LIPO NAD+ Complete system.

Low NAD+ levels manifest as chronic fatigue, brain fog, poor exercise recovery, disrupted sleep, accelerated skin aging, and reduced stress resilience. NAD+ levels begin declining significantly after age 30 and can be 50% lower by age 60 compared to youth. Liposomal NAD+ precursor supplementation is the most effective method to restore optimal levels.